Just finished Amazing Spider-Man #641 and I have to say that I was happy with the finality that Quesada gave to the M.J chapter of Peter Parker/Spider-Man's life.
Going into it, I was a bit uncertain what Marvel would be making out of One Moment In Time. Afterall, One More Day became an event to simply reset Peter Parker back to his youthful, single origins. Audiences love the Spider-Man story because he is the awkward guy trying to get the girl while juggling a day job and a night job as one of New York's finest super heroes. That massive swirling storm of problems and how Peter deals with them is why people gravitated to the character. However, over time, Peter needed to finally get the girl, and once M.J and Peter got married, he became a married man that resembled our fathers more than ourselves.
With One More Day--and Brand New Day--readers got the original Spider-Man back, but the story itself became a bit more unsatisfying than readers had hope. However, even though the event itself was a bit uneven, it's the stories we are now getting that make Spider-Man so enjoyable, but with the announcement of One Moment in Time, I wasn't sure if the four parter would be a gimmick or if the event would actually provide a good story.
Thankfully, O.M.I.T is actually pretty great. Not to do too much spoiling, but the event basically explains how the world forgot that Peter Parker was Spider-Man but using Tony Stark, Reed Richards, and Stephen Strange as the erasers rather than the demon Mephisto. The science behind it is definitely a bit hokey and you'll have to suspend your belief a bit if you want to be happy with the explanation (and since not too many panels are wasted on the explanation).
But what makes O.M.I.T so great is the story of time and change that Quesada is trying to tell. At some point in all of our lives, the status quo is changed and although we may not like it immediately, in time we realize that things can be good again. For Peter, that means letting go of M.J, and as upsetting as that might be for Peter and loyal Spidey readers, the well of stories that made us cheer for Petey when he was chasing Mary Jane is all but dried up. The character of Peter Parker needs to move on to a new chapter in his life (possibly even entering the Heroic Age of his life).
We may miss Mary Jane. We may miss the old days and the familiar stories, but change is never something that we want but often times something that we need. With O.M.I.T and the newer, fresher direction of the Spider-Man stories I think we'll eventually be okay without Mary Jane (although knowing comics, she won't be too far away...)